Merck 100590 1000 Glycine 1 KG.

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Description
Catalogue Number	100590
Synonyms	Gly, Aminoacetic acid, Aminoethanoic acid
Description	Glycine cryst.

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Product Information
CAS number	56-40-6
EC number	200-272-2
Grade	Ph Eur,BP,ChP,JP,USP
Hill Formula	C₂H₅NO₂
Chemical formula	H₂NCH₂COOH
Molar Mass	75.07 g/mol
HS Code	2922 49 85
Structure formula Image
Quality Level	MQ500

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Physicochemical Information
Density	1.161 g/cm3 (20 °C)
Melting Point	>233 °C (decomposition)
pH value	5.9 - 6.4 (50 g/l, H₂O, 20 °C)
Vapor pressure	0.0000171 Pa (25 °C)
Bulk density	920 kg/m3
Solubility	250 g/l soluble

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Toxicological Information
LD 50 oral	LD50 Rat 7930 mg/kg

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Safety Information according to GHS
RTECS	MB7600000
Storage class	10 - 13 Other liquids and solids
WGK	WGK 1 slightly hazardous to water
Disposal	3\nRelatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

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Storage and Shipping Information
Storage	Store at +2°C to +30°C.

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Transport Information
Declaration (railroad and road) ADR, RID	Kein Gefahrgut
Declaration (transport by air) IATA-DGR	No Dangerous Good
Declaration (transport by sea) IMDG-Code	No Dangerous Good

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Specifications
Assay (perchloric acid titration, calculated on dried substance)	99.0 - 101.0 %
Identity (IR-spectrum)	passes test
Identity (TLC)	passes test
Appearance	white to almost white, crystalline powder
Appearance of solution (100 g/l, CO₂-free water)	clear and colorless and not more intense in color than reference solution Y₇
Acidity (50g/l, water)	5.6 - 6.6
pH (50 g/l CO₂-free water)	5.9 - 6.4
Transmittance of solution (50 g/l, water)	≥ 98.0 %
Chloride (Cl)	≤ 70 ppm
Sulfate (SO₄)	≤ 60 ppm
Fe (Iron)	≤ 10 ppm
Heavy metals (as Pb)	≤ 10 ppm
As (Arsenic)	≤ 1 ppm
Hydrolyzable substances	passes test
Related substances (TLC)	passes test
Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)	≤ 0.10 %
Ninhydrin-positive substances (LC) (ammonium (570 nm))	≤ 0.02 %
Ninhydrin-positive substances (LC) (total impurities)	≤ 1.0 %
Related substances (HPLC) (Impurity B)	≤ 0.10 %
Related substances (HPLC) (Impurity H)	≤ 0.10 %
Related substances (HPLC) (Impurity I)	≤ 0.10 %
Related substances (HPLC) (unspecified impurities)	≤ 0.10 %
Sum of impurities (Ph Eur)	≤ 0.2 %
Related compounds (HPLC) (Glycine anhydride)	≤ 0.10 %
Related compounds (HPLC) (Iminodiacetic acid)	≤ 0.10 %
Related compounds (HPLC) (Diglycine)	≤ 0.10 %
Related compounds (HPLC) (Triglycine)	≤ 0.10 %
Related compounds (HPLC) (Hexamethylenetetramine)	≤ 0.10 %
Sum of impurities (USP)	≤ 1.0 %
Methanol (HS-GC)	≤ 3000 ppm
Other residual solvents (ICH Q3C)	excluded by manufacturing process
Loss on drying (105 °C, 2 h)	≤ 0.2 %
Sulfated ash (600 °C)	≤ 0.1 %
Bacterial endotoxins	≤ 2.0 I.U./g
Total aerobic microbial count (TAMC)	≤ 10 CFU/g
Total combined yeasts/moulds count (TYMC)	≤ 10 CFU/g
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph. Eur., BP, ChP, JP, USP