Merck 100844 2500 Ethanolamine suitable for use as excipient EMPROVE® 2,5 LT.

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Description
Catalogue Number	100844
Synonyms	2-Aminoethanol, Monoethanolamine

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Product Information
CAS number	141-43-5
EC index number	603-030-00-8
EC number	205-483-3
Grade	Ph Eur,BP,NF
Hill Formula	C₂H₇NO
Chemical formula	NH₂CH₂CH₂OH
Molar Mass	61.08 g/mol
HS Code	2922 11 00
Structure formula Image
Quality Level	MQ500

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Physicochemical Information
Boiling point	171 °C (1013 hPa)
Density	1.015 g/cm3 (20 °C)
Explosion limit	3.4 - 27 %(V)
Flash point	91 °C
Ignition temperature	410 °C
Melting Point	4 °C
pH value	12.1 (100 g/l, H₂O, 20 °C)
Vapor pressure	0.5 hPa (20 °C)
Viscosity kinematic	20 mm2/s (23 °C)

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Toxicological Information
LD 50 oral	LD50 Rat 1515 mg/kg
LD 50 dermal	LD50 Rabbit 1025 mg/kg

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Safety Information according to GHS
Hazard Pictogram(s)	\n\n
Hazard Statement(s)	H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.\nH314: Causes severe skin burns and eye damage.\nH335: May cause respiratory irritation.\nH412: Harmful to aquatic life with long lasting effects.
Precautionary Statement(s)	P273: Avoid release to the environment.\nP280: Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.\nP301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.\nP303 + P361 + P353: IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.\nP304 + P340 + P310: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.\nP305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Signal Word	Danger
RTECS	KJ5775000
Storage class	8A Combustible, corrosive hazardous materials
WGK	WGK 2 obviously hazardous to water
Disposal	3\nRelatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Safety Information
Categories of danger	harmful, corrosive

\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Storage and Shipping Information
Storage	Store at +15°C to +25°C.

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Transport Information
Declaration (railroad and road) ADR, RID	UN 2491 , 8, III
Declaration (transport by air) IATA-DGR	UN 2491 , 8, III
Declaration (transport by sea) IMDG-Code	UN 2491 , 8, III, Segregation Group: 18 (Alkalis)

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

Specifications
Assay (acidimetric)	98.0 - 100.5 %
Assay (acidimetric, calc. on anhydrous substance)	99.0 - 101.0 %
Identity (IR-spectrum)	conforms
Appearance	Clear, colorless or pale yellow liquid.
Appearance of solution (Ph Eur)	conforms
Refractive index (n 20/D)	1.453 - 1.459
Density (d 20/4)	1.014 - 1.017 g/cm³
Relative Density (d 20/20)	1.016 - 1.019
Specific gravity (d 25/25)	1.013 - 1.016
Weight per mL	1.014 - 1.023 g
Distilling range (167 °C - 173 °C)	≥ 95
Fe (Iron)	≤ 0.00001 %
Related substances (GC) (Diethanolamine)	≤ 0.5 %
Related substances (GC) (Triethanolamine)	≤ 0.5 %
Related substances (GC) (any other impurity)	≤ 0.5 %
Related substances (GC) (Sum of all impurities)	≤ 2.0 %
Related substances (GC) (Unspecified impurities) (Ph Eur)	≤ 0.10 %
Related substances (GC) (Total) (Ph Eur)	≤ 0.3 %
Residual solvents (ICH Q3C)	...excluded by production process
Residue on ignition (600 °C)	≤ 0.1
Water (according to Karl Fischer)	≤ 0.25 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Min. shelf life: see product label
Min. shelf life: see product label