Merck 100631 9024 Salicyclic Acid Emprove 20 KG.

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Description
Catalogue Number	100631
Synonyms	2-Hydroxybenzoic acid
Description	Salicylic acid

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Product Information
CAS number	69-72-7
EC number	200-712-3
Grade	Ph Eur,BP,USP
Hill Formula	C₇H₆O₃
Chemical formula	HOC₆H₄COOH
Molar Mass	138.12 g/mol
HS Code	2918 21 10
Structure formula Image
Quality Level	MQ500

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Physicochemical Information
Boiling point	211 °C (1013 hPa)
Density	1.44 g/cm3 (20 °C)
Flash point	157 °C
Ignition temperature	500 °C
Melting Point	158 - 160 °C
pH value	2.4 (H₂O, 20 °C) (saturated solution)
Vapor pressure	1 hPa (114 °C)
Bulk density	400 - 500 kg/m3
Solubility	2 g/l

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Toxicological Information
LD 50 oral	LD50 Rat 1250 - 1580 mg/kg
LD 50 dermal	LD50 Rat > 2000 mg/kg

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Safety Information according to GHS
Hazard Pictogram(s)	\n\n\n
Hazard Statement(s)	H302: Harmful if swallowed.\nH318: Causes serious eye damage.\nH361d: Suspected of damaging the unborn child.
Precautionary Statement(s)	P202: Do not handle until all safety precautions have been read and understood.\nP264: Wash skin thoroughly after handling.\nP280: Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.\nP301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.\nP305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.\nP308 + P313: IF exposed or concerned: Get medical advice/ attention.
Signal Word	Danger
RTECS	VO0525000
Storage class	10 - 13 Other liquids and solids
WGK	WGK 1 slightly hazardous to water
Disposal	3\nRelatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

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Safety Information
Categories of danger	harmful, irritant

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Storage and Shipping Information
Storage	Store at +15°C to +25°C.

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Specifications
Assay (acidimetric; calculated on dried substance)	99.5 - 100.5 %
Assay (HPLC, calc.on dried substance)	98.0 - 102.0 %
Identity	passes test
Appearance of solution (10 %; ethanol 96 %)	passes test
Chloride (Cl)	≤ 0.0100 %
Sulfate (SO₄)	≤ 0.0200 %
Related substances / HPLC (EP) (4-Hydroxybenzoic acid)	≤ 0.1 %
Related substances / HPLC (EP) (4-Hydroxyisophthalic acid)	≤ 0.05 %
Related substances / HPLC (EP) (Phenol)	≤ 0.02 %
Related substances / HPLC (EP) (Largest unspecified impurity)	≤ 0.05 %
Related substances / HPLC (EP) (Sum of all impurities)	≤ 0.2 %
Related substances / HPLC (USP) (4-Hydroxybenzoic acid)	≤ 0.1 %
Related substances / HPLC (USP) (4-Hydroxyisophthalic acid)	≤ 0.05 %
Related substances / HPLC (USP) (Phenol)	≤ 0.02 %
Related substances / HPLC (USP) (Largest unspecified impurity)	≤ 0.05 %
Related substances / HPLC (USP) (Sum of all impurities)	≤ 0.2 %
Residual solvents (ICH Q3C)	excluded by manufacturing process
Sulfated ash	≤ 0.05 %
Loss on drying	≤ 0.5 %
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).\ncorresponds to Ph Eur, BP, USP